Joaquin "El Chapo" Guzman, the world's most powerful drug kingpin, has now been accused of murder in the U.S. Forbes reports that a 21-count indictment that was read in the Eastern District of New York on Sept. 25 claims that "El Chapo" Guzman and Ismael "El Mayo" Zambada carried out "hundred of acts of violence including murders, assaults, kidnappings, assassinations and acts of torture." through the hiring of hitmen.

El Chapo was arrested earlier this year in Mexico and was credited as the most powerful kingpin in the world. Zambada worked as his right-hand man. It is now believed that Zambada, who is believed to be at large in the mountains of Sinaloa in Mexico, succeeded El Chapo as the man in charge of the criminal cartel.

The indictment lists individuals that the duo has killed including members of Mexican law enforcement, military personnel and public officials. Guzman and Zambada are also accused of murdering a number of presumed Mexican drug criminals as well as the attempted murders of several individuals whose names remain classified to all but members of the grand jury.

Further criminal syndicates that the two are have murdered or attempted to murder include members of the Beltran, Carillo Fuentes, Zeta and Felix Arrellano criminal organizations.

Assassinations of Raul LNU, known as "Robachivas" and Julia Beltran have also been pinned to Guzman and Zambada. The two criminals have not been charged for these murders in Mexico.

Furthermore, the indictment highlights the cartel's criminal activity pertaining to narcotics. The document sources, "a network of corrupt police and political contacts," used to direct the transportation of large amounts of cocaine through land, air and sea from South America, through Mexico, before finally settling in the U.S.

The cocaine sales would then generate billions of dollars in profits that were laundered back to Mexico, where Guzaman and Zambada and their empire flourished.

These newest charges have replaced a 2009 indictment that charged Guzman and other Mexican criminals with similar crimes.

Despite the sheer amount of federal charges El Chapo faces, the U.S. has not yet requested his extradition. Guzman is currently being held in high-security prison outside of Mexico City. Mexico has strongly opposed to idea of sending him to the States to face his charges.

This latest indictment does strengthen the case for a purposeful extradition should the U.S. decide to push for one. New York would likely be the first to try Guzman for these new murder charges.