Penelope Cruz sizzles in a sexy red leather jumpsuit on the set of "Zoolander 2" in Rome.

The 41-year-old actress, who shot scenes with both Ben Stiller and Owen Wilson, completed her outfit with a pair of studded red Christian Louboutin ankle boots. At some point during filming, the brunette beauty was seen riding a motorcycle.

Check out Cruz's photos in the sequel's production on Daily Mail.

Aside from Cruz, other celebrities set to have cameos in "Zoolander 2" are Kim Kardashian, Olivia Munn, Lewis Hamilton, and Kanye West, Daily Mail reported. Kristen Wiig will also appear in the sequel, as well as Billy Zane, Fred Armisen, and young actor Cyrus Arnold as Derek Zoolander's son, Derek Jr.

Stiller's wife Christine Taylor will also reprise her role as journalist Matilda Jeffries, with Will Ferrell expected to return to his character as Mugatu, Movie Web noted. Supermodel Karlie Kloss will also have a role in the film, Glamour Magazine wrote. Other supermodels on the sequel's shortlist include Naomi Campbell, Cara Delevingne, Jourdan Dunn, and Alessandra Ambrosio, E! News noted.

"I think the idea in the beginning of the movie is that it's 10 years later, and Derek and Hansel are literally forgotten," Stiller told MTV, speaking about the plot of "Zoolander 2." "Nobody remembers who they are, so they have to reinvent themselves. ... In the fashion world, if you go away for a year, it's changed -- it just happens so quickly."

The original film was released in theaters on September 29, 2001 just a few days after the 9/11 attack, Daily Mail wrote. Despite the movie's poor performance in the box office because of the tragedy, "Zoolander" became a huge hit when its DVD release came out.

According to Stiller, "Zoolander 2" is "going to drop like a giant bomb -- only a good bomb where that explodes with all this money that you can keep," as reported by Boston Herald.

Last March, Stiller and Wilson made a surprise appearance at the Valentino show at Paris Fashion Week as their respective characters in the comedy flick, a separate report from CNN noted. The publicity stunt saw Derek and his nemesis and sometimes BFF, Hansel, walking down the runway in Valentino attire.

The sequel, which is slated for release in theaters on February 12, 2016, is written by Justin Theroux and directed by Stiller, Glamour Magazine noted. Mayor of Rome Ignazio Marino has said that the follow-up will shoot for 12 weeks in and around the famous Cinecittà Studios.